LYMPHATIC RECONSTRUCTION FOR BRAIN DISEASE
What’s the proposed procedure and should it be done in a supermicro fashion?
Clinical studies and publications are summarized herein by MMI and are not intended to mislead or omit information. Please use the Read Publication button to review the full publication and associated data.
A proposed role for lymphatic supermicrosurgery in the management of Alzheimer’s disease: a primer for reconstructive microsurgeons
Focus: Explore the potential role of lymphatic supermicrosurgery as a novel surgical approach to improve lymphatic drainage and waste clearance in the brain for the management of Alzheimer’s disease (AD).
Method: Side (lymphatic)-to-end (venous) anastomosis of individual deep cervical lymphatic vessels directly to veins, or lymph-node-to-vein anastomosis. The method emphasizes using true supermicrosurgical tools and techniques to preserve remnant lymphatic function and maintain physiologic flow, minimizing the risk of complications or obstruction.
Limitation: Objective quantitative evidence, including biomarker measurements, is needed for validation.
Explore questions and research
What evidence supports existence of glymphatic and meningeal lymphatic pathways?
Image Source: Nature
Is there a mechanical problem to be addressed?
Image Source: JNM
Is there a causal relationship between protein levels and cognitive/functional decline in Alzheimer’s disease patients?
Image Source: NIH News
What is the anatomic target for a mechanical solution?
Image Source: The Radiology Assistant: Cervical Lymph Node Map
What’s the proposed procedure and should it be done in a supermicro fashion?
Image Source: APS
Is there evidence demonstrating the impact of the LVA/LNVA procedure in the neck?
Image Source: International Journal of Surgery
Pharmacologic treatments and severity distribution for Alzheimer’s disease
Image Source: NIH News
The information provided is solely for educational purposes relating to scientific information on the brain lymphatic system. Such summaries are not intended to mislead or omit information. Clinical studies and publications may be summarized herein. Click on each resource to access the full publication.
The safety and effectiveness of the Symani® Surgical System for lymphatic reconstruction for brain disease has NOT been established by any regulatory agency.
The Symani Surgical System is indicated in the U.S. for soft tissue manipulation in open microsurgical procedures to perform:
Anastomosis, suturing, and ligation microsurgery techniques on small blood vessels and lymphatic ducts between 0.1 and 2.5mm in open free-flap surgery of the breast, mouth, scalp, and extremities and in open lymphatic surgery of the extremities.
Dissection of soft tissues.
Clinical indications vary by geography. Refer to global indications for more information. For risks, cautions, warnings, and full prescribing information, please reference Symani safety and performance information.
